Dopamine

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Vijay Namboodiri and Ali Mohebi on the evolving story of dopamine’s role in cognitive function

Researchers discuss the classic stories of dopamine’s role in learning, ongoing work linking it to a wide variety of cognitive functions, and recent research suggesting that dopamine may help us "look back" to discover the causes of events in the world.

By Paul Middlebrooks
27 September 2024 | 97 min listen
Illustration of cranes attempting to assemble a structure out of very small black squares.

Reconstructing dopamine’s link to reward

The field is grappling with whether to modify the long-standing theory of reward prediction error—or abandon it entirely.

By Angie Voyles Askham
13 September 2024 | 20 min listen
Illustration of cranes attempting to assemble a structure out of very small black squares.

Dopamine and the need for alternative theories

Some experimental findings are inconsistent with the dominant model of reward prediction error, highlighting the need for alternative testable and falsifiable models for dopamine function.

By Vijay Mohan K. Namboodiri
13 September 2024 | 7 min read
Illustration of several structures constructed out of small black squares, with scaffolding on some of the structures.

Does a new theory of dopamine replace the classic model?

My answer would be no, but the model poses challenges that will sharpen our understanding of dopamine and learning.

By Naoshige Uchida
13 September 2024 | 8 min read
Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
A diagram of green neurnons

Cocaine, morphine commandeer neurons normally activated by food, water in mice

Confirming a long-held hypothesis, repeated exposure to the drugs alters neurons in the nucleus accumbens, the brain’s reward center, and curbs an animal’s urge for sustenance.

By Lauren Schenkman
8 May 2024 | 5 min read
Research images of the human motor cortex

What happens when a histopathologist teams up with computational modelers?

Answers emerge in my chat with Nicola Palomero-Gallagher, a rare example of someone who connects the brain’s microscopic constituents and macroscopic features.

By Mac Shine
11 December 2023 | 7 min read

Mouse study links dopamine in cerebellum to social behavior

The signaling molecule’s social role in the ‘little brain’ involves Purkinje neurons in the Crus I and Crus II regions, a new study reveals.

By Sarah DeWeerdt
6 July 2022 | 5 min read

Poor sleep shifts social circuit in mice

Even temporary bouts of too little non-REM sleep can lead to long-term changes in how the animals respond to certain social situations, new research suggests.

By Angie Voyles Askham
20 June 2022 | 5 min read
Brain scan showing communication from amygdala to hypothalamus about social reward.

Brain circuit makes social interactions rewarding, may be altered in autism

Blocking connections between the amygdala and hypothalamus prevents mice from finding social interactions as rewarding as they would otherwise.

By Angie Voyles Askham
30 April 2021 | 4 min read

Explore more from The Transmitter

Illustration of two neon-toned sets of concentric circles overlapping, with bright spots where they intersect.

Are Brains and AI Converging?—an excerpt from ‘ChatGPT and the Future of AI: The Deep Language Revolution’

In his new book, to be published next week, computational neuroscience pioneer Sejnowski tackles debates about AI’s capacity to mirror cognitive processes.

By Terrence Sejnowski
21 October 2024 | 12 min read

New tissue-clearing techniques let microscopes peer deeper into living brains

Washing mouse brain tissue with a blood protein or complex sugar can illuminate cells 550 micrometers into the cortex without compromising its normal physiology.

By Calli McMurray
18 October 2024 | 0 min watch
A younger looking set of hands holds an older looking set of hands.

New catalog charts familial ties from autism to 90 other conditions

The research tool reveals associations stretching across three generations.

By Charles Q. Choi
17 October 2024 | 4 min read